This issue is a mind-twisting tour-de-force on the art end, combining the surreal visual styles of Nemo creator Winsor McCay with the equally confounding styles of artist M.C. Escher, known for his optical trickery, and cartoonist Gustave Verbeek, whose 1903-05 comic strip “The Upside Downs of Little Lady Lovekins and Old Man Muffaroo” had the unusual property of being read twice, once normally and once upside down, with characters that combined images to work that way, as in the main figure here. The storyline is equally clever, with some pages being upside-down versions of others. The content of the story is fairly slight, Nemo and Flip are being chased essentially, but there’s so much going on visually it’s hard to see how a deeper story could have been managed. Impressive and fascinating.